Jodie Foster claims that during the first meeting between Lecter and Starling, Anthony Hopkins’s mocking of her southern accent was not rehearsed and that Hopkins improvised it on the spot. Foster’s reaction of horror was totally genuine, as she felt personally attacked, though she later thanked Hopkins for generating such an honest reaction.

When Ted Tally was writing the screenplay for the film, he suggested Jodie Foster for role of Clarice Starling. Foster had been lobbying hard for the part from the start but when Jonathan Demme was hired to direct the film, he felt she was wrong for the part and wanted Michelle Pfeiffer instead. Pfeiffer turned the part down because she felt the film was too violent. Demme then agreed to meet Foster and hired her after only one meeting because he said he could see her strength and determination for the part that he felt was perfect for the character of Clarice.